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Optimal

Psychological and Physical Fatigue

60 gélules pour 1 mois

OPTIMAL is the advanced Cellular Nutrition protocol formulated by Dr. Espinasse to act on the core biological mechanisms of fatigue — whether physical, mental, or stress-related — and to support long-term global energy.


This food supplement combines a major adaptogenic plant, Rhodiola, key amino acids including L-Tyrosine, Coenzyme Q10, and selected probiotic strains, chosen for their complementary and synergistic actions: together, they support mitochondrial energy production, regulation of the stress response, and restoration of neuropsychic balance, while preserving metabolic and digestive integrity.


By targeting mitochondrial dysfunction, neuroendocrine imbalance, and disruption of the gut–brain axis commonly associated with chronic fatigue, OPTIMAL helps restore mental clarity, alertness, motivation, and adaptive capacity over time; its integrative formulation is particularly suited to periods of prolonged stress, overwork, poor recovery, convalescence, or intense physical and cognitive demand.


OPTIMAL is recommended in cases of persistent or chronic fatigue, reduced concentration, alertness issues, or irritability, prolonged stress and difficult recovery, stress- or metabolic fatigue-related headaches, as well as during periods of convalescence or sustained effort; it forms part of a global vitality approach, supporting physical, mental, and cellular energy over the long term.

Key bioavailable active ingredients RHODIOLA / COENZYME Q10 / TYROSINE

single bottle 65.00€
3-bottle pack -10% on pack of 3 : 58.50€ per unit instead of 65.00€
175.50€ 195€
select a quantity
vegetable capsule
vegan
gluten-free
lactose-free
GMO-free

Integrated actions & benefits

OPTIMAL works at a deep biological level, targeting the cellular, mitochondrial and neuroendocrine pathways involved in fatigue — whether physical, mental or driven by prolonged stress. Its formulation supports energy production at the heart of the cell, while helping to regulate the neurochemical and hormonal responses essential for sustained alertness, focus and stress resilience. By improving energy availability and stabilising neurotransmission, OPTIMAL helps restore mental clarity, motivation and adaptive capacity during periods of overload, recovery or intense physical and cognitive demand. Its adaptogenic action enables the body to better tolerate both physical and emotional strain, without excessive stimulation or disruption of the nervous system. By addressing the gut–brain–metabolism axis, OPTIMAL also supports nutrient absorption and digestive balance, which are often compromised in chronic fatigue states. It is a key supplement for reactivating overall energy — physical, mental and cellular — and for supporting the body over time whenever performance, recovery and stress tolerance are put to the test.

Integrated mechanisms of action

Mitochondrial activation: stimulation of ATP synthesis through CoQ10.

Stress adaptation: cortisol modulation and neurotransmitter support via Rhodiola and Tyrosine.

Neuropsychic balance: restoration of dopaminergic and serotonergic pathways.

Microbiota support: optimisation of metabolic exchanges and micronutrient assimilation.

Scientifically documented active ingredient synergy

  • A major adaptogenic plant, Rhodiola helps the body adapt to physical and emotional stress. Its active compounds (rosavins and salidrosides) modulate cortisol secretion and support brain functions involved in alertness and resilience. Multiple studies have demonstrated its effects in reducing fatigue, improving mental performance, and alleviating symptoms of overwork and mild anxiety.
  • Rhodiola also acts on dopaminergic and serotonergic neurotransmission, promoting emotional balance and faster recovery after exertion.
  • An amino acid essential to healthy brain function, L-Tyrosine is the direct precursor of catecholamines (dopamine, adrenaline, noradrenaline) — neurotransmitters that govern alertness, motivation, and stress management. During prolonged fatigue, tyrosine reserves may deplete, leading to reduced clarity, focus, and mental drive.
  • Targeted supplementation supports neurotransmitter synthesis, helping to restore adaptability and cognitive performance, particularly in conditions of stress, extended effort, or lack of sleep.
  • Present in all cells, coenzyme Q10 (ubiquinone) plays a central role in ATP production — the body’s primary energy source. It acts within the mitochondrial respiratory chain, ensuring efficient conversion of nutrients into usable energy.
  • With age, oxidative stress or nutritional deficiencies, endogenous CoQ10 levels decline, compromising muscular and cognitive vitality. Supplementation helps optimise energy output, reduce fatigue, and strengthen the antioxidant protection of cells.
  • The intestinal microbiota directly influences energy production, B-vitamin synthesis, and regulation of the gut–brain axis. Certain probiotic strains modulate stress, immunity, and nutrient bioavailability.
  • OPTIMAL includes strains selected for their effect on digestive comfort, production of energetic metabolites, and regulation of overall tone.

Scientific studies

1 — 3

Systematic review and meta-analysis (2022) — Tsai et al., Frontiers in Pharmacology
Coenzyme Q10 (CoQ10) significantly reduces fatigue, with dose- and duration-dependent effects and good overall tolerability.

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In case of fatigue, you need to act on different pillars to regain lasting vital energy

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