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Slim

Weight Management and Blood Sugar Regulation

60 gélules pour 1 mois

SLIM is the advanced Cellular Nutrition protocol formulated by Dr. Espinasse to address overall metabolic imbalance by supporting blood sugar regulation, energy utilisation, and long-term metabolic flexibility.


This food supplement combines targeted metabolic actives, Berberine, Gymnema, and Coleus, with selected probiotic strains, chosen for their complementary and synergistic actions: together, they activate cellular energy pathways, improve insulin sensitivity, limit glycaemic spikes, and promote fat mobilisation, while supporting intestinal microbiota balance.


By targeting insulin resistance, glycaemic dysregulation, slowed metabolism, and low-grade inflammation commonly associated with weight gain, SLIM helps reduce sugar cravings, abdominal fat accumulation, and metabolic fatigue; its integrative formulation is particularly suited to individuals experiencing resistance to weight loss or recurrent cravings.


SLIM is recommended in cases of weight gain linked to glycaemic imbalance, sugar cravings and snacking urges, abdominal fat and slow metabolism, as well as metabolic fatigue or resistance to weight loss; it forms part of a global metabolic regulation approach, supporting long-term weight management, cellular energy, and glycaemic stability.

Key bioavailable active ingredients COLEUS / BERBERINE / GYMNEMA

single bottle 65.00€
3-bottle pack -10% on pack of 3 : 58.50€ per unit instead of 65.00€
175.50€ 195€
select a quantity
vegetable capsule
vegan
gluten-free
lactose-free
GMO-free

Integrated actions & benefits

By acting simultaneously on metabolic, hormonal and digestive pathways, SLIM targets the biological mechanisms underlying resistant weight gain and glycaemic imbalance. Its formulation supports metabolic flexibility — the body’s ability to efficiently use both sugars and fats as energy sources — which is essential for sustainable fat loss. SLIM helps stabilise blood sugar levels, limit insulin spikes and reduce sugar cravings, which are key drivers of abdominal fat storage and metabolic fatigue. At the same time, it stimulates energy-burning pathways and lipolysis, supporting the gradual mobilisation of fat reserves while preserving lean mass, energy levels and overall vitality. By addressing the gut–liver–metabolism axis, SLIM also contributes to reducing low-grade inflammation and optimising the metabolic microbiota — two central levers in weight regulation. This integrative approach supports fat loss without disrupting physiological balance, while maintaining digestive comfort, emotional stability and metabolic performance. SLIM is therefore a key supplement for supporting long-term weight regulation and restoring functional metabolic balance.

Integrated mechanisms of action

Metabolic activation: stimulation of AMPK and mitochondrial lipolysis (Berberine, Coleus).

Glycaemic regulation: improved insulin sensitivity and reduced intestinal glucose absorption (Gymnema, Berberine).

Fat mass reduction: increased lipid combustion and thermogenesis.

Metabolic microbiota balance: improved bacterial composition and reduction of low-grade inflammation.

Scientifically documented active ingredient synergy

  • A natural alkaloid extracted from Berberis aristata, berberine acts on several key metabolic pathways.
  • It activates the AMPK enzyme (AMP-activated protein kinase), the body’s true cellular “energy switch”, which stimulates fat burning, improves insulin sensitivity, and regulates hepatic glucose production.
  • Its effects are comparable to metformin in glycaemic control, but without side effects.
  • Berberine helps reduce fasting glucose, triglycerides, LDL cholesterol, and systemic inflammation.
  • It also supports microbiota health by promoting metabolically beneficial bacteria such as Akkermansia muciniphila.
  • Native to India, Gymnema is known as “gurmar”, meaning “sugar destroyer”. Its gymnemic acids temporarily block sweet taste receptors and reduce intestinal glucose absorption.
  • It helps curb sugar cravings and postprandial glycaemic spikes.
  • Gymnema also supports insulin secretion and beta-cell regeneration in the pancreas, contributing to better glycaemic control and gradual reduction of body fat.
  • Coleus contains forskolin, an active molecule that increases intracellular cAMP (cyclic adenosine monophosphate), a key messenger involved in fat mobilisation.
  • This activation stimulates lipolysis (breakdown of triglycerides), promotes fatty acid release, and supports mitochondrial thermogenesis.
  • It helps reduce fat mass, particularly abdominal fat, while supporting lean mass and muscular energy.
  • The intestinal microbiota plays a decisive role in weight regulation and metabolism. Dysbiosis contributes to inflammation, insulin resistance, and fat storage tendencies.
  • The probiotic strains in SLIM help modulate energy metabolism, reduce intestinal permeability, and produce metabolites that improve insulin sensitivity.
  • They also support fat digestion and transit regulation, often disrupted during dieting.

Scientific studies

1 — 3

Meta-analysis (2023) — Feng et al., Frontiers in Nutrition, University of Melbourne & Johns Hopkins University
Berberine significantly lowers fasting glucose, HbA1c and triglyceride levels, with efficacy comparable to metformin and excellent overall tolerability.

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